Additionally, previous research revealed that probiotics Clostridium butyricum could similarly increase the expression of the IL-10 and HSP-70 in weaning rex rabbits (Liu et al., 2019) and colon cancer HT-29 cells (Andriamihaja et al., 2009; Meng et al., 2021). This evidence concerns the gene IL10 and malignant colon neoplasm.