Elmadbouh I and Singla DK found that diabetic cardiomyopathy involves sterile inflammation and causes the upregulation of NLRP3-Nek7-GBP5 inflammasome complex, which finally initiates Caspase-1-dependent pyroptosis in diabetic cardiomyopathy. The gene discussed is NLRP3; the disease is diabetic cardiomyopathy.