Pyroptosis (Caspase-1, IL-1β, IL-18,)↓; Cardiac fibrosis (MMP-9) ↓; Cardiac hypertrophy and dilation↓; Inflammasome formation (TLR4-NLRP3)↓; Inflammatory cytokines (IL-6, TNF-α)↓; Inflammatory cells (CD14, iNOS, CD11b, CD11c)↓; Adverse cardiac remodeling↓; EPC markers and neovascularization (c-Kit/Flk-1 and CD31/α-SM actin)↑; Cardiac function↑. This evidence concerns the gene NOS2 and cardiac hypertrophy.