Meanwhile, bone morphogenetic protein-7 (BMP-7)can inhibit the NLRP3 inflammasome complex and their activator Nek7-GBP5, and the subsequent cascade of pyroptosis in diabetic cardiomyopathy, attenuate inflammatory infiltrated dendritic and M1 macrophages, reducing inflammation and adverse cardiac remodeling through enhanced neovascularization following BMP-7 treatment while improving heart function BMP-7 attenuated inflammation-induced pyroptosis, adverse cardiac remodeling, and improved heart function via the TLR4-NLRP3 inflammasome complex activated by novel signaling Nek7/GBP5 (33). The gene discussed is TLR4; the disease is diabetic cardiomyopathy.