Caspase-1 is an important regulator of the inflammatory response, activated Caspase-1 can trigger pyroptosis, and the release of pro-inflammatory cytokines IL-1β and IL-18 can cause the amplification of inflammatory cascade, resulting in endothelial dysfunction, and then produce or increase the development of myocardial fibrosis. The gene discussed is CASP1; the disease is endothelial dysfunction.