NLRP3 and myocardial infarction: NLRP3 inflammasome activation mainly occurs in cardiac fibroblasts during myocardial remodeling and repair (68), activates IL-1β release and pyroptosis in cardiac fibroblasts after myocardial infarction (MI) (69).A significant increase in expression of pyroptosis and MMP9 in cardiac fibrosis in diabetes (33, 70).