NLRP3 and diabetic cardiomyopathy: Echocardiogram data suggests impaired LV function in diabetic cardiomyopathy, diabetic cardiac systolic and diastolic dysfunction can be preserved by inhibiting pyroptosis proteins (33), CD74 ablation protects against Type 2 diabetes-induced cardiac remodeling and contractile dysfunction through NLRP3/pyroptosis-mediated regulation of ferroptosis (101).