CASP1 and myocardial infarction: It was found that the amount of ASC, NLRP3, and Caspase-1 in myocardial cells at the edge of AMI increased significantly with time, and the level of NLRP3 in myocardial fibroblasts in ischemic myocardium increased significantly, inhibition of NLRP3 activation could reduce the size of MI and preserve the function of myocardial after infarction (85).