Streptozotocin (STZ)-induced diabetic cardiomyopathy significantly increased inflammasome formation (TLR4, NLRP3, Nek7, and GBP5), which induced the occurrence of pyroptosis, accompanied by the increased of inflammatory cytokines (IL-6 and TNF-α), MMP9, infiltration of monocytes (CD14), macrophage (iNOS), and dendritic cells (CD11b and CD11c). Here, TLR4 is linked to diabetic cardiomyopathy.