NLRP3 inflammasome activation mainly occurs in cardiac fibroblasts during myocardial remodeling and repair (68), activates IL-1β release and pyroptosis in cardiac fibroblasts after myocardial infarction (MI) (69).A significant increase in expression of pyroptosis and MMP9 in cardiac fibrosis in diabetes (33, 70). Here, MMP9 is linked to myocardial infarction.