KL and congestive heart failure: After controlling for the model 3 described above, Klotho had a significant direct effect on the prevalence of CHF (all p < 0.001), and eGFR, BUN, UA, and UACR partly mediated the indirect effect of Klotho on the prevalence of CHF (all p < 0.05), with eGFR, BUN, UA, and UACR estimated to explain 19.51, 6.98, 13.93, and 0.71% of the association between Klotho and CHF, respectively (Figures 2A–D).