It was found to regulate cell proliferation in a variety of cell lines, including ECV304 (an endothelial cell‐derived cell line), PLC/PRF/5 (liver cancer cell line), SMMC‐7721 (liver cancer cell line) and HepG2 (human hepatoma cell lines, HCC cell lines), gastric cancer cell lines (MKN74, AGS, MGC‐803, SGC‐7901, and HGC‐27), etc.4, 7, 9, 10During embryonic development, CDK5RAP3 interacts with CBP (cAMP response element‐binding protein [CREB]‐binding protein), p25, and plays a key role in neuronal proliferation, migration and differentiation.11 This evidence concerns the gene CREB1 and liver cancer.