PRC1 and cancer: In addition, histone H2A mono-ubiquitination (H2Aub) is catalysed by PRC1 and removed by the PcG-repressive deubiquitinase (PR-DUB)/BAP1 complex, and H2Aub deposition can interplay with PRC2-catalysed histone H3K27 methylation—this crosstalk is also involved in cancer pathologies (see review by Barbour et al. [193]).