Moreover, TCGA data in GEPIA database showed that there was a marked positive correlation between the expression levels of SRSF9 and methyltransferase METTL3 (R = 0.7, P < 0.001) (Fig. 6G), as well as DSN1 and METTL3 (R = 0.56, P < 0.001) (Fig. 6H) in CRC tissues. This evidence concerns the gene METTL3 and colorectal carcinoma.