CYP2E1 and neoplasm: We investigated: (1) whether CYP2E1 has a protective role in the malignant biological behavior of HCC; (2) if so, whether CYP2E1 acts as a tumor suppressor by regulating the Wnt/β-catenin pathway in HCC, and (3) the potential links between CYP2E1 suppression and the Wnt/β-catenin pathway in HCC.