Our research found that m6A-mediated macrophage, especially for HNRNPA2B1 + mac-C3 subtypes, manifested obvious activation of metabolism-related pathways, such as purine biosynthesis, gluconeogenesis, and cysteine and methionine metabolism et al. Moreover, except for macrophages, we found that m6A-mediated T cells (CD8+, CD4+ and regulatory T cells), NK cells and B cells also showed extensive interaction with tumor cells. Here, HNRNPA2B1 is linked to neoplasm.