Furthermore, Cellphone analysis showed that ligand-receptor pairs, including MIF −  (CD74 + CXCR4), MIF −  (CD74 + CD44), MDK–NCL, LGALS9 − CD45, CLEC2D − KLRB1, CLEC2C − KLRB1, CLEC2B − KLRB1, APP − CD74, CD99 − CD99, and ADGRE5 − CD55 mediated the communication between m6A associated subtypes of TME cells and tumor epithelial cells. This evidence concerns the gene ADGRE5 and neoplasm.