By the cell-chat analysis, we listed all ligand-receptor pairs of intercellular communication, including MIF −  (CD74 + CXCR4), MIF −  (CD74 + CD44), MDK–NCL, LGALS9 − CD45, CLEC2D − KLRB1, CLEC2C − KLRB1, CLEC2B − KLRB1, APP − CD74, CD99 − CD99, and ADGRE5 − CD55, were existed from m6A sub clusters to the tumor epithelial cells (Fig. 6A and Additional file 1: Table S4). The gene discussed is NUCLEOLIN; the disease is neoplasm.