Grasset et al. reported that high expression of Cav1.1 promotes the collective migration of squamous cell carcinoma cells by increasing intracellular Ca2+, while Cav1.1 gene silencing by using blockers (diltiazem and verapamil) of L-type Ca2+ channels decreases the invasive properties of tumor cells both in vitro and in vivo [39]. This evidence concerns the gene CACNA1S and squamous cell carcinoma.