Meanwhile, we analyzed the protein expression of the four candidate genes CACNA1S, ATP2A1, RYR1, and MYLK3 by IHC staining, then focused on the differences of their expression between tumor cells of MAC, syringoma, trichoepithelioma, basal cell carcinoma-infundibulocystic type and normal sweat glands. The gene discussed is RYR1; the disease is basal cell carcinoma.