PBX3 and hepatocellular carcinoma: Functionally, the CCK-8 assay, colony formation assay and migration and invasion assays demonstrated that ectopic overexpression of miR-516a-5p or knockdown of PBX3 could partially rescued the circTOLLIP-induced promotion of proliferation, migration, and invasion in HCC cells (Fig. 7h-l; Additional file 13: Fig. S13a-d).