Cardio-facio-cutaneous syndrome (CFCS) belongs to RASopathies, a group of conditions caused by germline mutations in genes encoding components or regulators of the rat sarcoma/mitogen-activated protein kinase (RAS/MAPK) pathway [1], main mechanism regulating cell growth and differentiation, proliferation, migration, and apoptosis [2]. The gene discussed is WNK2; the disease is sarcoma.