At LiT AR sites, we selected genes that were up-regulated in normal prostate epithelium relative to local tumor (n = 186); at GiT AR sites, we selected genes up-regulated in localized prostate tumor relative to normal epithelium (n = 159); at LiM AR sites, we selected genes up-regulated in local tumor relative to prostate metastases (n = 156); and at GiM AR sites, we selected genes up-regulated in prostate metastases relative to local tumor (n = 267) (Fig. 1B). The gene discussed is P4HB; the disease is neoplasm.