They showed that ablation of HIF-1α resulted in lower expression of its downstream targets such as vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9), ensuring reduced metastasis and ameliorating the paclitaxel-driven cytotoxicity on human pancreatic cancer cell line BxPC-3 in vitro and in vivo [184]. Here, HIF1A is linked to familial pancreatic carcinoma.