In addition to MUC5AC, it has been proposed that ablation of partitioning defective 3-like protein (Par3L) 108, a recently described cell polarity protein, and nuclear factor-erythroid factor 2-related factor 2 (Nrf2) [122], a critical transcription factor, may attenuate CRC cell resistance to chemotherapies and irradiation. Here, MUC5AC is linked to colorectal carcinoma.