PTPN1 and neurodegenerative disease: Increases in the activity of PTP1B, just like stress in the endoplasmic reticulum, have been associated with metabolic disturbances both in the periphery and central areas and, have been linked with a diverse array of pathological states, including neurodegenerative diseases (Thiebaut et al. 2016; Ono 2019; Chen et al. 2015; Verma and Sharma 2018; Ravichandran et al. 2001).