Steady progress has been made to elucidate disease mechanisms on a placental level and molecular markers such as the sFlt-1/PIGF ratio (soluble Fms-like Tyrosinkinase-1/Placental growth factor) (Levine et al. 2004; Zeisler et al. 2016) have improved prediction for occurrence of preeclampsia. The gene discussed is PIGF; the disease is preeclampsia.