Ranking gene family expansion/contractions by p-values and retaining only Bos gaurus gene families that changed by more than one gene copy revealed that the top 10 gene families with the most significant gene gains were: Inner Membrane Transporter YGJI-Related, Vomeronasal Type-1 Receptor, Apolipoprotein L, Transmembrane Protein 181, Hypothetical Protein Loc689039, Tropomyosin, Translation Machinery-Associated Protein 7, Small Integral Membrane Protein 15 and Diabetes and Obesity Regulated, Isoform G (Supplementary Table 6). The gene discussed is VN1R1; the disease is obesity due to melanocortin 4 receptor deficiency.