LRP1 and central nervous system cancer: LRP‐1 is highly expressed on brain capillary endothelial and glioma cells, and these characteristics make angiopep‐2 a promising candidate for LRP1‐mediated targeted drug delivery to glioblastoma.[19] Therefore, we added ANG peptide to the fusion gene of Lamp2b to obtain ANG peptide‐modified engineered exosomes and obtain stronger BBB penetration and brain targeting ability.