LRP‐1 is highly expressed on brain capillary endothelial and glioma cells, and these characteristics make angiopep‐2 a promising candidate for LRP1‐mediated targeted drug delivery to glioblastoma.[19] Therefore, we added ANG peptide to the fusion gene of Lamp2b to obtain ANG peptide‐modified engineered exosomes and obtain stronger BBB penetration and brain targeting ability. This evidence concerns the gene ANG and central nervous system cancer.