Further tumor growth between VCaP control or VCaP PGC1α knockdown xenograft animals not subjected to STF were comparable, indicating that PGC1α’s tumor-promoting function is activated only under starvation resulting in ERG-mediated ROS clearance and anti-apoptotic functions in control animals but fails in absence of PGC1α (Figs. S4i and 4i). This evidence concerns the gene PPARGC1A and neoplasm.