In patients with relapse, several clinical and biological markers associated with RA disease activity (disease activity score on 28 joints-CRP (DAS28-CRP), simplified disease activity index (SDAI), clinical disease activity index (CDAI), Health Assessment Questionnaire (HAQ), and patient global assessment with visual analog scale (Pt-VAS)) were significantly higher than those in patients with remission. This evidence concerns the gene CRP and rheumatoid arthritis.