Further examination showed that about 40% of high-confidence (family-wise error rate ≤ 0.05) autism spectrum disorder candidate genes38, including Grin2b, Scn2a1 (also known as Scn2a) and Slc6a1, contained NE-open chromatin regions and ERα occupancy (Extended Data Fig. 8j and Supplementary Table 6). Here, SCN2A is linked to autism spectrum disorder.