We also performed an LV-dose–response of LV.coFVIII.XTEN in neonatal hemophilia and achieved between 5 and 82 ng/mL of circulating FVIII concentration and between 0.05 and 0.6 U/mL of FVIII activity (corresponding to 5 to 60–80% of normal) with an increasing LV dose–response relationship (Fig. 2h, i). Here, F8 is linked to hemophilia.