F8 and hemophilia A: We then treated neonatal hemophilia A mice with increasing doses of LV.coFVIII ranging from 2.2 × 109 TU/kg to 3.5 × 1010 TU/kg and detected circulating FVIII concentration and activity only at the 2 highest doses, which were on average 23 ng/mL, 276 mU/mL (corresponding to 23–28% of normal) at 1.7 × 1010 TU/kg LV dose and 401 ng/mL, 7635 mU/mL (40–76% of normal) at 3.5 × 1010 TU/kg LV-dose (Fig. 2e, f).