Combining these results with the aforementioned validation of the circ_0000811/miR-15b/Prkar2a and Prkar2a/JAK2/STAT1 mediatory axes, our data elucidated that circ_0000811 could ameliorate CI-induced vertigo through modulating the miR-15b/Prkar2a/JAK2/STAT1 axis in mice. Here, PRKAR2A is linked to Vertigo.