SIRT1 and Dyggve-Melchior-Clausen disease: In general, we identified 12 DE-lncRNAs related to DMC, among which lncRNA LYPLAL1-DT was identified to be transmitted from leukocytes to ECs via exosomes and have protective effects on EC as ceRNA mediated through the miR-204-5p/SIRT1 pathway.