SIRT1 and Dyggve-Melchior-Clausen disease: We identified new lncRNAs related to DMC abnormal endothelial cells and further explored the protective effects of lncRNA LYPLAL1-DT as a ceRNA to inhibit miR-204-5p and upregulate SIRT1 in order to promote autophagy of endothelial cells (EC), as well as ameliorate inflammation of EC.