VCAN and myeloid sarcoma: We conducted spatial RNA sequencing (spRNAseq) (Jain et al., in preparation) of post-mortem MS brain tissue section which showed elevated levels of versican mRNA in the inactive demyelinated lesion, and to a lesser extent in the active core, compared to normal appearing white matter (NAWM) or to non-MS controls (Supplementary Fig. 2a, b).