No significant differences could be appreciated in absolute counts of neutrophils and monocytes (data not shown), or monocyte subpopulations distribution, absolute counts and percentages of monocytic-like derived suppressor cells CD14+-HLA-DR− cells (panels E–F).Sera of breakthrough COVID-19 patients were able to induce more NET-osis in vitro than not vaccinated patients, associated to increased percentage (mean 38.5 ± 4.2 vs 24.1 ± 5.7%, p = 0.04, panel G) and density (mean 227.5 ± 3.2 vs 35.6 ± 7.4, cells/μm2, p < 0.0001, panel H). Here, CD14 is linked to COVID-19.