The percentage and counts of immune-suppressive monocytes (mo-MDSCs) identified as CD14+ HLA-DR− monocytes were higher than normal values in severe COVID-19+ patients (Fig. 4D), independently from the amount of IL-6, IL-1β, IL-17A, TGF-β, TNF-α and IFN-γ. This evidence concerns the gene CD14 and COVID-19.