Previous studies have evidenced the association of APOE alleles with susceptibility to infection by viruses, with elevated levels of lipoprotein(a) (Lp(a)), with local extracellular vesicle biogenesis in the brain, with the levels of the Willebrand factor and the modulation of angiotensin converting enzyme 2 (ACE2)20,22–27. The gene discussed is APOE; the disease is infection.