We predicted the E3 ubiquitin ligase of NLRP3 through UbiBrowser database (http://ubibrowser.ncpsb.org/ubibrowser/home/index) and intersected the results with the downregulated gene in the sepsis-related microarray GSE100159, whereby WWP1 was the only gene identified (Fig. 1A, B). Here, NLRP3 is linked to Sepsis.