We evaluated the clinicopathological correlates of the 7 SMGs, together with 6 additional cancer genes identified from at least 2 previous HCC genomics studies3,36–38 and mutated in ≥3 HCCs of the current cohort (APOB, ARID2, CDKN2A, KEAP1, RB1 and TSC2). This evidence concerns the gene KEAP1 and hepatocellular carcinoma.