Among the selected antiviral candidate genes, only 2 had a significant impact on SARS-CoV-2 replication: LY6E (as expected), and to an even greater degree, DAXX. Both genes restricted replication in absence of IFNα, an effect which was detectable at the level of viral RNA (8-fold and 42-fold reduction of infection, respectively, Fig. 2a) and of infectious virus (15-fold and 62-fold reduction, Fig. 2b). Here, IFNA1 is linked to infection.