Furthermore, the TME is the internal environment not just for tumour cells to generate and develop, but also other tumour supporting cells, such as immune cells and fibroblasts fibroblasts, which can induce the release of IL-6 by activating YAP-TAZ pathway, as well as NF-κB and TNF-α, thereby contributing to immune cell infiltration and promotion of tumor progression [37]. The gene discussed is TNF; the disease is neoplasm.