After adjustments for cancer purity in LUSC and LUAD, POSTN expression was strongly associated with the presence of B cells, CD8+ T cells, CD4+ T cells, neutrophils, dendritic cells, monocytes, and various functional T cells, including T helper, Tregs, resting Treg, effector Treg, naïve T cells, effector T cells, resistant memory, and exhausted T cells. Here, CD4 is linked to cancer.