ELOVL4 and retinal degeneration: Studies of a large familial group with retinal degeneration revealed an autosomal dominant macular dystrophy phenotype which results from a 5-bp deletion, causing Stargardt-like macular dystrophy [184,185], and an STGD3 mouse Elovl4 mutation produces a C32-C36 PC deficiency [186], leading to the suggestion that loss or reduced VLC-PUFAs may cause loss of photoreceptors or functional perturbations [187], highlighting the importance of these molecules in the retina.