MUC16 and neoplasm: To date, conventional serum tumor markers are applied in GC screening, including carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), cancer antigen 19-9(CA19-9), cancer antigen 72-4(CA72-4) and cancer antigen 125(CA125), and are also used in the predicting of the prognosis, recurrence, or metastasis [9–11].