In the recent PRONOUNCE study of prostate cancer patients with concomitant atherosclerotic cardiovascular diseases, major adverse cardiovascular events at 1 year occurred in 5.5% of patients assigned to the GnRH antagonist degarelix and similarly in 4.1% assigned to the GnRH agonist leuprolide [72]. The gene discussed is GNRH1; the disease is Familial prostate cancer.