Sonkodi et al. postulated that the overall proprioceptive system is neuro-energetically resource-limited and implicated the channelopathy of Piezo2 as a primary injury phase of an acute non-contact compression axonopathy in certain conditions, such as delayed-onset muscle soreness and non-contact anterior cruciate ligament (NC-ACL) injury (Sonkodi et al. 2021a, 2020; Sonkodi 2021). Here, PIEZO2 is linked to channelopathy.