Again, it is worth noting that the suggested Piezo2 channelopathy is a critical gateway to pathophysiology through a non-contact injury mechanism, and this critical pathway and the involvement of parallel signaling pathways and multiple factors, like the impact of environmental factors and genetic predisposition (see Table 1) such as Piezo mutations, should be considered in this heterogeneous clinical picture. Here, PIEZO2 is linked to channelopathy.