To evaluate the in vivo antitumor potential of proCAR T cells as a function of receptor oligomeric state, we engrafted NOD-SCID-IL2RG-/- (NSG) mice with the aggressive MC38 mouse colon adenocarcinoma cell line engineered to stably express HER2 and treated them 1 day later with a single intravenous injection of CD8+ CAR T cells (Figure 5a). Here, CD8A is linked to colon adenocarcinoma.