CTSB and malaria: The choice of covalent warhead is dependent on the relative hardness/softness of the nucleophile‐electrophile pairs, particularly relevant when targeting cysteine and serine.[9, 10] Like for the general ABPP field, malaria studies of specific enzymes have focused mostly on cysteine proteases and serine hydrolases, with a few studies extending to the targeting of the proteasome and metalloenzymes.