TGFB1 and neoplasm: Hypoxia is one of the main pathological features of most solid tumor microenvironment (Wilson & Hay, 2011; Yang et al., 2019) and the hypoxia tumor cells lead to immunosuppression tumor microenvironment by accumulating immunosuppressive cells and secreting immunosuppressive factors, such as TGF-β (Yang et al., 2021).