Human epidermal growth factor receptor 2 (HER2) is often expressed in a variety of tumors tissues and is closely related to the development of carcinoma, while HER2 activates the downstream signaling pathways through heterodimer and tyrosine kinase autophosphorylation mediated signal transduction (De Santis et al., 2019; Akbari et al., 2020); and which gene magnification and protein overexpression play a crucial role in the cell proliferation, adhesion, aggressiveness apoptosis as well angiogenesis of numerous solid tumors (Kaur & Dasanu, 2011). This evidence concerns the gene ERBB2 and carcinoma.