(1) Specifically binds tumor cells and mediates endocytosis: The HER-2 antibodies of RC-48 bind with high molecular affinity to the extracellular realm of HER2 on the surface of malignant cells, subsequently causing clathrin-based and caveolin-based endocytosis of RC48-ADC, which is further transported to lysosomes (Li et al., 2020). Here, ERBB2 is linked to neoplasm.