Moreover, tumor‐derived factors, such as IL1, IL6, IL8, IL11, TNFα, prostaglandin E2 (PGE2), and S100A4 protein activate osteoclasts in a RANKL‐dependent or independent manner (Fig 3D) (Kim et al, 2019; Haider et al, 2021; Venetis et al, 2021). The gene discussed is IL1B; the disease is neoplasm.