Metastatic cancer cell activity upregulates osteoblast‐specific markers, including alkaline phosphatase (ALP) and Runt‐related transcription factor (RUNX2), as well as factors regulating bone turnover, such as osteoprotegerin, osteopontin, parathyroid hormone‐related peptide (PTHrP), receptor activator of nuclear factor kappa‐B ligand (RANKL), and macrophage colony‐stimulating factor (M‐CSF) (Fig 3D) (Gao et al, 2019). Here, SPP1 is linked to cancer.