Furthermore, interaction of metastatic cancer cells with the hematopoietic niche is mediated by α4β1‐vascular cell adhesion molecule 1 (VCAM1), chemokines like CXCL12, BMP, Notch, Nestin, and osteopontin (Weilbaecher et al, 2011). This evidence concerns the gene CXCL12 and cancer.