CCL2 and neoplasm: Tumor‐derived cytokines and chemokines such as CCL2, mentioned above, recruit regulatory and immunosuppressive immune cells, including tumor‐associated macrophages (TAMs), to secondary organs, where they are potent orchestrators of PMN formation through immune‐modulation and immune‐suppression (Qian et al, 2011; Bonapace et al, 2014; Ozga et al, 2021).