At the same time, a new study shows that Wnt5a/JNK3 is involved in the ischemia-reperfusion process of hippocampal CA1 area, and interfering with Wnt5a/JNK3 signaling pathway may provide a new way for the treatment of stroke [48], the above suggests that Wnt5a/JNK3 may be involved in the occurrence and development of cardiovascular diseases. This evidence concerns the gene MAPK10 and stroke disorder.