SFRP5 and neoplasm: Wnt5a, as one of the interacting binding proteins of SFRP5, has been reported to be involved in tumor progression [45,46], the above studies suggest that Wnt5a is involved in the process of angiogenesis and cell proliferation of a variety of cells, but there is no report on Wnt5a in vascular endothelium and vascular proliferation.