The results showed that the expressions of Wnt5a, p-JNK1/JNK1, p-JNK2/JNK2, p-JNK3/JNK3 were significantly up-regulated in HG induced HUVECs and T2DM-MI mouse models, while SFRP5 down regulated the levels of Wnt5a, p-JNK1/JNK1, p-JNK2/JNK2, p-JNK3/JNK3. The gene discussed is MAPK8; the disease is type 2 diabetes mellitus.