In addition, western blot results showed that compared with the control group, the expression of Wnt5a, p-JNK1/JNK1, p-JNK2/JNK2, p-JNK3/JNK3 in T2DM and T2DM + MI + vector groups increased, and SFRP5 down regulated the levels of Wnt5a, p-JNK1/JNK1, p-JNK2/JNK2, p-JNK3/JNK3 (P < 0.05, Figure 4(c)). The gene discussed is MAPK8; the disease is type 2 diabetes mellitus.