Abnormally high expression levels of BBOX1-AS1 are observed in most cancers, such as lung [7], cervical [8], and esophageal cancers [9], and BBOX1-AS1 is strongly linked to the overall survival of patients with these cancers, which suggests that targeting BBOX1-AS1 may be used as a therapeutic approach for cancer treatment. The gene discussed is BBOX1; the disease is esophageal cancer.