Systemic and pulmonary Ang II levels have been reported to be elevated in patients with idiopathic PAH and are associated with increased pulmonary vascular remodeling,11 while serum ACE2 levels are reported to be decreased in patients with congenital heart disease‐associated PAH and correlate with mean PAP (mPAP).19 This evidence concerns the gene AGT and pulmonary arterial hypertension.