SYNE1 is associated with Emery–Dreifuss muscular dystrophy (Chen et al., 2017; Heller et al., 2020; Sandra et al., 2019), and mutation of DMD, as the largest in the human genome (total intron content: >2.2 Mb) (Keegan, 2020), causes Duchenne muscular dystrophy and Becker muscular dystrophy (Yang et al., 2019). This evidence concerns the gene DMD and Duchenne muscular dystrophy.