For this reason, we consider the neurological adverse effects of atherosclerosis and the effects of arteriosclerosis on other poor outcome factors.As a neurological adverse effect of atherosclerosis, decreased protective factors, such as nitric oxide (NO), endogenous tPA, decreased collateral circulation, atherosclerotic cerebral microcirculatory disorders, and gradual obstruction of penetrating branches, may cause damage to the vascular endothelium and blood-brain barrier (BBB), resulting in damage to the brain parenchyma [18-24]. This evidence concerns the gene PLAT and arteriosclerosis.