TTE, TEE, or bubble contrast echocardiography and coronary angiography. Thrombophilia screening with factor V Leiden, prothrombin 20210A, factor VIII, proteins C and S, antithrombin, lupus anticoagulant, and antiphospholipid antibodies should all be included in the work-up. Here, F2 is linked to Rare hereditary thrombophilia.