COVID-19 has been associated with the thyroid function through Angiotensin-converting enzyme 2 (ACE2), the central mechanism through Thyroid Stimulating Hormone (TSH), and direct replication of the virus.<h4>Case presentation</h4>A 26-year-old woman presented with complaints of palpitation and abdominal pain for three days. The gene discussed is ACE2; the disease is COVID-19.