ESR1 and neoplasm: The pHER2Y1248 status did not significantly correlate with tumor size (r = 0.037; P = 0.683), lymph node status (r = -0.056, P = 0.539), histological grade (r = -0.010, P = 0.912), intrinsic subtype (r = -0.113, P = 0.211), or the expression of ER (r = -0.147, P = 0.103) and PgR (r = -0.037, P = 0.683) (Table 2 and Table 3).