Many immune‐related activities, including complement activation and humoral immune response, were also significantly enriched between the two IHRGPI groups in both GO and GSEA functional enrichment analysis, and CD8 T cells, the most powerful effector cells in the anticancer immune response,46 were more abundant in the tumor microenvironment of HNSCC patients in both the “high immunity” and radiosensitive groups in comparison with the “low immunity” and radioresistant groups, respectively. The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.