SERPINE1 also plays an important role in the HIF1 pathway by increasing oxygen delivery in response to hypoxia,34 and was also included in previously proposed gene signatures to predict locoregional tumor control for HNSCC patients treated with postoperative radiotherapy35 or the response to neo‐adjuvant chemoradiotherapy before surgery for locally advanced esophageal cancer.36 This evidence concerns the gene SERPINE1 and esophageal cancer.