LncRNA KB-1980E6.3 binds to insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) to form a complex under the induction of HIF-1α to recognize m6A modified c-myc coding region instability determinant (CRD) mRNA and enhance the stability of c-myc mRNA, which significantly promotes the stemness and proliferation of breast cancer stem cells (BCSCs) in hypoxic tumor microenvironment [94]. This evidence concerns the gene IGF2BP1 and breast carcinoma.