An inadequate cortisol response to ACTH stimulation can result from prior glucocorticoid administration, treatment with drugs that suppress adrenal function such as ketoconazole, reduced potency of the ACTH due to storage, inappropriate dose of ACTH, errors in ACTH administration or sample collection, non-cortisol secreting adrenal tumours and critical illness related adrenal insufficiency [41]. The gene discussed is POMC; the disease is Adrenal insufficiency.